Reduced V1 vasopressin binding in the rat nucleus solitarii after nodose ganglionectomy.

Details

Serval ID
serval:BIB_9802FFD861DC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Reduced V1 vasopressin binding in the rat nucleus solitarii after nodose ganglionectomy.
Journal
Clinical and Experimental Pharmacology and Physiology
Author(s)
Phillips P.A., Widdop R.E., Chai S.Y., Kelly J., Mooser V., Trinder D., Johnston C.I.
ISSN
0305-1870 (Print)
ISSN-L
0305-1870
Publication state
Published
Issued date
1990
Volume
17
Number
4
Pages
321-325
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
1. Anaesthetized male Sprague-Dawley rats underwent unilateral nodose ganglionectomy or sham operation. 2. One week later hindbrain V1 vasopressin binding site density was assessed by in vitro autoradiography with the selective V1 antagonist radioligand [125I] [d(CH2)5, Sar7]AVP. 3. Specific binding was observed in the nodose ganglion, nucleus tractus solitarius (NTS), area postrema, and inferior olive. Only binding in the medial subnucleus of the NTS was reduced by ipsilateral nodose ganglionectomy. 4. These findings are consistent with V1 vasopressin receptors occurring presynaptically on vagal primary viscerosensory afferent fibres. 5. Such receptors may be involved in the effect of AVP on blood pressure and/or the baroreflex.
Keywords
Animals, Ganglionectomy, Male, Medulla Oblongata/metabolism, Nodose Ganglion/physiology, Rats, Rats, Inbred Strains, Receptors, Angiotensin/metabolism, Receptors, Vasopressin, Rhombencephalon/metabolism, Vagus Nerve/physiology, Vasopressins/metabolism
Pubmed
Web of science
Create date
13/10/2013 21:05
Last modification date
20/08/2019 14:59
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