Recognition of Intracellular Bacteria by Inflammasomes.
Details
Serval ID
serval:BIB_9706BF5CAE4E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Recognition of Intracellular Bacteria by Inflammasomes.
Journal
Microbiology spectrum
ISSN
2165-0497 (Electronic)
ISSN-L
2165-0497
Publication state
Published
Issued date
03/2019
Peer-reviewed
Oui
Volume
7
Number
2
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Inflammasomes are multiprotein signaling complexes that are assembled by cytosolic sensors upon the detection of infectious or noxious stimuli. These complexes activate inflammatory caspases to induce host cell death and cytokine secretion and are an essential part of antimicrobial host defense. In this review, I discuss how intracellular bacteria are detected by inflammasomes, how the specific sensing mechanism of each inflammasome receptor restricts the ability of bacteria to evade immune recognition, and how host cell death is used to control bacterial replication in vivo.
Keywords
Adaptor Proteins, Signal Transducing/metabolism, Animals, Anti-Infective Agents/pharmacology, Apoptosis Regulatory Proteins/metabolism, Bacteria/isolation & purification, Bacteria/pathogenicity, CARD Signaling Adaptor Proteins/metabolism, Calcium-Binding Proteins/metabolism, Cell Death, Cytokines/metabolism, Cytosol/microbiology, DNA-Binding Proteins/metabolism, Humans, Immune Evasion, Inflammasomes/immunology, Inflammasomes/metabolism, NLR Family, Pyrin Domain-Containing 3 Protein/metabolism, Neuronal Apoptosis-Inhibitory Protein/metabolism, Pyrin/metabolism, Pyroptosis/drug effects, Signal Transduction/immunology
Pubmed
Web of science
Create date
08/04/2019 17:59
Last modification date
20/08/2019 15:59
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