Adeno-associated virus (AAV) as a vector for gene transfer into glial cells of the human central nervous system.

Details

Serval ID
serval:BIB_96F03E3C4643
Type
Article: article from journal or magazin.
Collection
Publications
Title
Adeno-associated virus (AAV) as a vector for gene transfer into glial cells of the human central nervous system.
Journal
Gene Therapy
Author(s)
Tenenbaum L., Darling J.L., Hooghe-Peters E.
ISSN
0969-7128 (Print)
ISSN-L
0969-7128
Publication state
Published
Issued date
1994
Volume
1
Number
Suppl 1
Pages
S80
Language
english
Notes
abstract ?
Abstract
To examine the potential of AAV as a vector for gene transfer in glial cells, an established astrocytoma cell line and short-term cultures derived from human oligodendroglioma have been coinfected with AAV and helper adenovirus. The level of AAV replication in glioma cells was high indicating that they express receptors for AAV.
Keywords
Astrocytoma/therapy, Astrocytoma/virology, Brain Neoplasms/therapy, Brain Neoplasms/virology, Dependovirus/genetics, Dependovirus/physiology, Gene Therapy, Gene Transfer Techniques, Genetic Vectors, Humans, Oligodendroglioma/therapy, Oligodendroglioma/virology, Tumor Cells, Cultured, Virus Replication
Pubmed
Create date
01/04/2011 10:16
Last modification date
20/08/2019 14:58
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