Hyperreninemia and secondary hyperaldosteronism in a patient with pheochromocytoma and von Hippel-Lindau disease

Details

Serval ID
serval:BIB_962C9ADDA9DF
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Hyperreninemia and secondary hyperaldosteronism in a patient with pheochromocytoma and von Hippel-Lindau disease
Journal
Nephron
Author(s)
Lenz  T., Thiede  H. M., Nussberger  J., Atlas  S. A., Distler  A., Schulte  K. L.
ISSN
0028-2766 (Print)
Publication state
Published
Issued date
1992
Volume
62
Number
3
Pages
345-50
Notes
Case Reports
Journal Article
Abstract
In a 21-year-old Caucasian women with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of captopril further enhanced renin secretion, while her blood pressure improved. The patient became normokalemic following tumor removal, and her blood pressure decreased to normal levels with reestablishment of normal circadian blood pressure rhythm. This case demonstrates that, in the absence of renovascular or malignant hypertension, pheochromocytoma can be the underlying cause for the clinical syndrome of hypertension associated with severe hypokalemia and hyperreninemic hyperaldosteronism.
Keywords
Adrenal Gland Neoplasms/*complications Adult Captopril/diagnostic use Catecholamines/blood Clonidine/diagnostic use Female Hippel-Lindau Disease/*complications/genetics Humans Hyperaldosteronism/*complications Hypertension/drug therapy Pheochromocytoma/*complications Renin/*blood
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 14:58
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