Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Hyperreninemia and secondary hyperaldosteronism in a patient with pheochromocytoma and von Hippel-Lindau disease
In a 21-year-old Caucasian women with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of captopril further enhanced renin secretion, while her blood pressure improved. The patient became normokalemic following tumor removal, and her blood pressure decreased to normal levels with reestablishment of normal circadian blood pressure rhythm. This case demonstrates that, in the absence of renovascular or malignant hypertension, pheochromocytoma can be the underlying cause for the clinical syndrome of hypertension associated with severe hypokalemia and hyperreninemic hyperaldosteronism.
Adrenal Gland Neoplasms/*complications Adult Captopril/diagnostic use Catecholamines/blood Clonidine/diagnostic use Female Hippel-Lindau Disease/*complications/genetics Humans Hyperaldosteronism/*complications Hypertension/drug therapy Pheochromocytoma/*complications Renin/*blood
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