An unusual uterine tumour with signet ring cell features

Details

Serval ID
serval:BIB_95D7A46274C8
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
An unusual uterine tumour with signet ring cell features
Title of the conference
22nd European Congress of Pathology
Author(s)
Rossella S., Fiche M., Achtari C., Ketterer N., de Laval L.
Address
Florence, Italy, September 4-9, 2009
ISBN
0945-6317
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
457
Series
Virchows Archiv
Pages
195
Language
english
Notes
Meeting Abstract
Abstract
Objective: Lymphomas with signet ring cell features are
rare, as is uterine dissemination of lymphomas. We report
an exceptional case of a uterine tumor combining these two
characteristics.
Method: A 61-year-old female was diagnosed in 2004 with
localized nodal grade 2 follicular lymphoma (stage IA). She
received local radiation therapy, experienced total remission,
and did well until 2009 when a systematic CT scan
evidenced a pelvic anterior-lateral mass. Total enlarged
hysterectomy was performed.
Results: The anterior uterine wall contained a 4.8-cm fish
flesh well-delineated mass corresponding to a mostly
diffuse and focally nodular proliferation of medium to
large cells with extensive signet ring cell changes. Tumor
cells were CD20-, CD10-, Bcl2-, and Bcl6-positive with a
low proliferation rate (<10-15%); CD21 underlined a focal
follicular architecture. The vacuoles were PAS-negative and
did not stain for immunoglobulin; ultrastructural analysis
revealed nonspecific degenerative vacuoles. No lymph
nodes were identified isolated from the surgical specimen.
The tumor was considered as a secondary localization of
the systemic follicular lymphoma, though no signet ring
cells were evidenced in the cervical lymph node biopsy
(reviewed). Follow-up showed retroperitoneal tissue infiltration
(PET-CT) and normal medullar biopsy. She recently
started R-CHOP chemotherapy.
Conclusion: This case illustrates both an unusual site of
dissemination and challenging cytological characteristics in
a follicular lymphoma. The signet ring cell changes
challenged the adequate classification of this lymphoma as
either a large B cell or a follicular B cell lymphoma.
Web of science
Create date
01/09/2010 8:23
Last modification date
20/08/2019 14:58
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