Comparative modular analysis of gene expression in vertebrate organs.

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Serval ID
serval:BIB_94FEE072331D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Comparative modular analysis of gene expression in vertebrate organs.
Journal
Bmc Genomics
Author(s)
Piasecka B., Kutalik Z., Roux J., Bergmann S., Robinson-Rechavi M.
ISSN
1471-2164 (Electronic)
ISSN-L
1471-2164
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
13
Pages
124
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
ABSTRACT:
BACKGROUND: The degree of conservation of gene expression between homologous organs largely remains an open question. Several recent studies reported some evidence in favor of such conservation. Most studies compute organs' similarity across all orthologous genes, whereas the expression level of many genes are not informative about organ specificity.
RESULTS: Here, we use a modularization algorithm to overcome this limitation through the identification of inter-species co-modules of organs and genes. We identify such co-modules using mouse and human microarray expression data. They are functionally coherent both in terms of genes and of organs from both organisms. We show that a large proportion of genes belonging to the same co-module are orthologous between mouse and human. Moreover, their zebrafish orthologs also tend to be expressed in the corresponding homologous organs. Notable exceptions to the general pattern of conservation are the testis and the olfactory bulb. Interestingly, some co-modules consist of single organs, while others combine several functionally related organs. For instance, amygdala, cerebral cortex, hypothalamus and spinal cord form a clearly discernible unit of expression, both in mouse and human.
CONCLUSIONS: Our study provides a new framework for comparative analysis which will be applicable also to other sets of large-scale phenotypic data collected across different species.
Pubmed
Web of science
Open Access
Yes
Create date
09/03/2012 9:38
Last modification date
20/08/2019 15:57
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