Guidelines on statistics for researchers using laboratory animals: the essentials.

Details

Serval ID
serval:BIB_94D6593CC4D1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Guidelines on statistics for researchers using laboratory animals: the essentials.
Journal
Laboratory animals
Author(s)
Gosselin R.D.
ISSN
1758-1117 (Electronic)
ISSN-L
0023-6772
Publication state
Published
Issued date
02/2019
Peer-reviewed
Oui
Volume
53
Number
1
Pages
28-42
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
There is growing concern that the omnipresence of flawed statistics and the deficient reproducibility that arises therefrom results in an unethical waste of animals in research. The present review aims at providing guidelines in biostatistics for researchers, based on observed frequent mistakes, misuses and misconceptions as well as on the specificities of animal experimentation. Twelve recommendations are formulated that cover sampling, sample size optimisation, choice of statistical tests, understanding p-values and reporting results. The objective is to expose important statistical issues that one should consider for the correct design, execution and reporting of experiments.
Keywords
Animal Experimentation/statistics & numerical data, Animals, Laboratory Animal Science/methods, Research Design, Sample Size, Statistics as Topic/methods, experimental design, guidelines, reproducibility, sample size, statistics
Pubmed
Web of science
Create date
17/08/2018 17:54
Last modification date
20/08/2019 15:57
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