Autophagy induction does not protect retina against apoptosis in ischemia/reperfusion model.

Details

Serval ID
serval:BIB_9431B272BE4D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Autophagy induction does not protect retina against apoptosis in ischemia/reperfusion model.
Journal
Advances In Experimental Medicine and Biology
Author(s)
Produit-Zengaffinen N., Pournaras C.J., Schorderet D.F.
ISSN
0065-2598 (Print)
ISSN-L
0065-2598
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
801
Pages
677-683
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The role played by autophagy after ischemia/reperfusion (I/R) in the retina remains unknown. Our study investigated whether ischemic injury in the retina, which causes an energy crisis, would induce autophagy. Retinal ischemia was induced by elevation of the intraocular pressure and modulation of autophagic markers was analyzed at the protein levels in an early and late phase of recovery. Following retinal ischemia an increase in LC3BII was first observed in the early phase of recovery but did not stay until the late phase of recovery. Post-ischemic induction of autophagy by intravitreal rapamycin administration did not provide protection against the lesion induced by the ischemic stress. On the contrary, an increase in the number of apoptotic cells was observed following I/R in the rapamycin treated retinas.
Pubmed
Web of science
Create date
07/04/2014 11:28
Last modification date
19/03/2018 10:52
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