Targeting the Wnt pathways for therapies

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_9410B64D2CF5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Targeting the Wnt pathways for therapies
Journal
Molecular and Cellular Therapies
Author(s)
Blagodatski A., Poteryaev D., Katanaev V.L.
ISSN
2052-8426 (Electronic)
ISSN-L
2052-8426
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
2
Pages
28
Language
english
Notes
Publication types: Review ; review-article Identifiant PubMed Central: PMC4452063
Abstract
The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance. Namely, improper activation of this pathway is carcinogenic in many tissues, most notably in the colon, liver and the breast. On the other hand, the Wnt/β-catenin signaling must be re-activated in cases of tissue damage, and insufficient activation results in regeneration failure and degeneration. These both medically important implications are unified by the emerging importance of this signaling pathway in the control of proliferation of various types of stem cells, crucial for tissue regeneration and, in case of cancer stem cells - cancer progression and relapse. This article aims at briefly reviewing the current state of knowledge in the field of Wnt signaling, followed by a detailed discussion of current medical developments targeting distinct branches of the Wnt pathway for anti-cancer and pro-regeneration therapies.
Keywords
Wnt, Frizzled, Cancer, Regeneration, Drug discovery
Pubmed
Open Access
Yes
Create date
11/07/2016 10:04
Last modification date
20/10/2020 8:19
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