Effect of propofol on cerebrospinal fluid pressure and cerebral perfusion pressure in patients undergoing craniotomy

Details

Serval ID
serval:BIB_93ED64D8A018
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of propofol on cerebrospinal fluid pressure and cerebral perfusion pressure in patients undergoing craniotomy
Journal
Anaesthesia
Author(s)
Ravussin  P., Guinard  J. P., Ralley  F., Thorin  D.
ISSN
0003-2409
Publication state
Published
Issued date
03/1988
Peer-reviewed
Oui
Volume
43 Suppl
Pages
37-41
Notes
Journal Article --- Old month value: Mar
Abstract
The effects of propofol on cerebrospinal fluid pressure, mean arterial pressure, cerebral perfusion pressure and heart rate were studied during induction, tracheal intubation and skin incision in 23 patients scheduled for elective craniotomy. Premedication consisted of midazolam 0.1 mg/kg intramuscularly and metoprolol 1 mg/kg orally. Measurements were made or derived at time zero and 0.5, 1, 1.5, 2 and 3 minutes after an induction dose of propofol 1.5 mg/kg. A continuous infusion of propofol was started at time zero at a rate of 100 mg/kg/minute. Fentanyl 2 micrograms/kg was added before tracheal intubation, application of the pin head holder and skin incision. Cerebrospinal fluid pressure and mean arterial pressure decreased significantly 2 minutes after propofol alone, by 32% and 10% respectively, while a cerebral perfusion pressure above 70 mmHg was maintained. Heart rate did not change. Propofol combined with moderate dose of fentanyl, obtunded the usual cerebrospinal fluid and arterial pressure responses to intubation and other noxious stimuli. Thus propofol seems to be a suitable intravenous anaesthetic agent for induction and maintenance in neuroanaesthesia.
Keywords
Anesthesia, Intravenous Anesthetics/*pharmacology Blood Pressure/drug effects Cerebrovascular Circulation/*drug effects *Craniotomy Drug Evaluation Humans Intracranial Pressure/*drug effects Middle Aged Phenols/*pharmacology Propofol Time Factors
Pubmed
Web of science
Create date
17/01/2008 16:19
Last modification date
20/08/2019 14:56
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