Granulocyte-macrophage colony-stimulating factor and the immune system
Details
Serval ID
serval:BIB_93B5F9C4C9F4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Granulocyte-macrophage colony-stimulating factor and the immune system
Journal
Medical Oncology
ISSN
1357-0560
Publication state
Published
Issued date
09/1996
Peer-reviewed
Oui
Volume
13
Number
3
Pages
133-40
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine currently used for the reversal of neutropenia associated with cytotoxic chemotherapy, bone marrow and haemopoietic stem cell transplantation. GM-CSF also modulates the function of differentiated white blood cells. In the context of local inflammatory responses, GM-CSF stimulates macrophages for antimicrobial and antitumor effects. GM-CSF further enhances healing and repair by its actions on fibroblasts and epidermal cells. GM-CSF is the pivotal mediator of the maturation and function of dendritic cells, the most important cell type for the induction of primary T cell immune responses. GM-CSF may enhance antibody dependent cellular cytotoxicity (ADCC) in several cell types, and the generation and cytotoxicity of natural killer (NK) cells. On this basis, GM-CSF may be useful for inducing or augmenting antibody responses to antimicrobial vaccines, to enhance killing of intracellular microorganisms, to accelerate epidermal and mucosal wound healing, and to stimulate protective immunity against tumors.
Keywords
Adjuvants, Immunologic
Animals
Antibody Formation
Antibody-Dependent Cell Cytotoxicity/immunology
Dendritic Cells/immunology
Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology/*physiology
Hematopoiesis/drug effects
Humans
*Immune System
Immunotherapy
Killer Cells, Natural/immunology
Wound Healing/drug effects
Pubmed
Web of science
Create date
20/01/2008 16:55
Last modification date
20/08/2019 14:56