Efficacy of subinhibitory concentration of pefloxacin in preventing experimental Staphylococcus aureus foreign body infection in mice

Details

Serval ID
serval:BIB_92B51722F39B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Efficacy of subinhibitory concentration of pefloxacin in preventing experimental Staphylococcus aureus foreign body infection in mice
Journal
Drugs Under Experimental and Clinical Research
Author(s)
Carsenti-Etesse  H., Entenza  J., Durant  J., Pradier  C., Mondain  V., Bernard  E., Dellamonica  P.
ISSN
0378-6501 (Print)
Publication state
Published
Issued date
1992
Volume
18
Number
10
Pages
415-22
Notes
Journal Article
Abstract
Adhesion is the first step leading to colonization and infection of a foreign body (FBI). To assess the ability of a subinhibitory concentration (subMIC) of pefloxacin (P) to prevent such infection, an experimental model was developed in Swiss albino mice. Subcuts of polyurethane catheters (Vygon) were placed in the peritoneal cavity of animals and 24 hours later, different inocula of an adherent strain of Staphylococcus aureus (SA) (MIC of P:0.8 mg/l) were injected i.p. Unexposed SA served as controls. Two days later the removed catheters, blood and spleen specimens were quantitatively cultured for bacterial content and identity. Infection was defined as more than 10 CFU/ml of SA recovered. Significant protection of mice, with lower dissemination, was found with inoculum sizes of 10(5) and 10(6). These results suggest that subMICs of P may confer protection against foreign body infection.
Keywords
Animals Bacterial Adhesion Disease Models, Animal Female Foreign Bodies/*complications Mice Pefloxacin/administration & dosage/*therapeutic use Peritoneal Cavity/microbiology Spleen/microbiology Staphylococcal Infections/etiology/microbiology/*prevention & control Staphylococcus aureus/growth & development/pathogenicity
Pubmed
Web of science
Create date
24/01/2008 13:45
Last modification date
20/08/2019 14:55
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