HIV and Aging - Perhaps Not as Dramatic as We Feared?

Details

Serval ID
serval:BIB_92146D8F7DD2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
HIV and Aging - Perhaps Not as Dramatic as We Feared?
Journal
Gerontology
Author(s)
Engel T., Raffenberg M., Marzolini C., Cavassini M., Kovari H., Hasse B., Tarr P.E.
ISSN
1423-0003 (Electronic)
ISSN-L
0304-324X
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
64
Number
5
Pages
446-456
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed.
Keywords
AIDS Dementia Complex/etiology, AIDS-Associated Nephropathy/etiology, Adult, Aged, Aging, Antiretroviral Therapy, Highly Active/adverse effects, Atherosclerosis/complications, Atherosclerosis/diagnostic imaging, Body Composition, Cardiovascular Diseases/complications, Drug Interactions, Fractures, Bone/complications, Frailty/complications, HIV Infections/complications, HIV Infections/drug therapy, HIV Infections/mortality, Humans, Life Expectancy/trends, Male, Metabolic Diseases/etiology, Middle Aged, Risk Factors, Telomere Homeostasis, Comedications, Comorbidities, Drug interactions, Frailty, HIV, Polypharmacy
Pubmed
Web of science
Create date
23/07/2018 17:25
Last modification date
20/08/2019 15:55
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