The systemic control of circadian gene expression.

Details

Serval ID
serval:BIB_91A53EF0E384
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The systemic control of circadian gene expression.
Journal
Diabetes, Obesity and Metabolism
Author(s)
Gerber A., Saini C., Curie T., Emmenegger Y., Rando G., Gosselin P., Gotic I., Gos P., Franken P., Schibler U.
ISSN
1463-1326 (Electronic)
ISSN-L
1462-8902
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
17 Suppl 1
Pages
23-32
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The mammalian circadian timing system consists of a central pacemaker in the brain's suprachiasmatic nucleus (SCN) and subsidiary oscillators in nearly all body cells. The SCN clock, which is adjusted to geophysical time by the photoperiod, synchronizes peripheral clocks through a wide variety of systemic cues. The latter include signals depending on feeding cycles, glucocorticoid hormones, rhythmic blood-borne signals eliciting daily changes in actin dynamics and serum response factor (SRF) activity, and sensors of body temperature rhythms, such as heat shock transcription factors and the cold-inducible RNA-binding protein CIRP. To study these systemic signalling pathways, we designed and engineered a novel, highly photosensitive apparatus, dubbed RT-Biolumicorder. This device enables us to record circadian luciferase reporter gene expression in the liver and other organs of freely moving mice over months in real time. Owing to the multitude of systemic signalling pathway involved in the phase resetting of peripheral clocks the disruption of any particular one has only minor effects on the steady state phase of circadian gene expression in organs such as the liver. Nonetheless, the implication of specific pathways in the synchronization of clock gene expression can readily be assessed by monitoring the phase-shifting kinetics using the RT-Biolumicorder.
Keywords
Animals, CLOCK Proteins/metabolism, Circadian Clocks/physiology, Circadian Rhythm/genetics, Circadian Rhythm/physiology, Equipment Design, Gene Expression, Genes, Reporter/physiology, Glucocorticoids/physiology, Liver/metabolism, Luciferases/genetics, Luciferases/metabolism, Mice, Signal Transduction/genetics, Suprachiasmatic Nucleus/physiology
Pubmed
Web of science
Open Access
Yes
Create date
17/09/2015 13:09
Last modification date
20/08/2019 15:54
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