Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.

Details

Serval ID
serval:BIB_919CC4A77FE2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Journal
Nature communications
Author(s)
Collins S.C., Mikhaleva A., Vrcelj K., Vancollie V.E., Wagner C., Demeure N., Whitley H., Kannan M., Balz R., Anthony LFE, Edwards A., Moine H., White J.K., Adams D.J., Reymond A., Lelliott C.J., Webber C., Yalcin B.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
01/08/2019
Peer-reviewed
Oui
Volume
10
Number
1
Pages
3465
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here we analyze 118 neuroanatomical parameters in 1,566 mutant mouse lines and identify 198 genes whose disruptions yield NeuroAnatomical Phenotypes (NAPs), mostly affecting structures implicated in brain connectivity. Groups of functionally similar NAP genes participate in pathways involving the cytoskeleton, the cell cycle and the synapse, display distinct fetal and postnatal brain expression dynamics and importantly, their disruption can yield convergent phenotypic patterns. 17% of human unique orthologues of mouse NAP genes are known loci for cognitive dysfunction. The remaining 83% constitute a vast pool of genes newly implicated in brain architecture, providing the largest study of mouse NAP genes and pathways. This offers a complementary resource to human genetic studies and predict that many more genes could be involved in mammalian brain morphogenesis.
Pubmed
Web of science
Open Access
Yes
Create date
18/08/2019 16:17
Last modification date
21/08/2019 6:32
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