Geometric control of the cell cycle.
Details
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State: Public
Version: Final published version
State: Public
Version: Final published version
Serval ID
serval:BIB_918B2853B9FA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Geometric control of the cell cycle.
Journal
Cell Cycle
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
8
Number
22
Pages
3643-3647
Language
english
Abstract
How do cells sense their own size and shape? And how does this information regulate progression of the cell cycle? Our group, in parallel to that of Paul Nurse, have recently demonstrated that fission yeast cells use a novel geometry-sensing mechanism to couple cell length perception with entry into mitosis. These rod-shaped cells measure their own length by using a medially-placed sensor, Cdr2, that reads a protein gradient emanating from cell tips, Pom1, to control entry into mitosis. Budding yeast cells use a similar molecular sensor to delay entry into mitosis in response to defects in bud morphogenesis. Metazoan cells also modulate cell proliferation in response to their own shape by sensing tension. Here I discuss the recent results obtained for the fission yeast system and compare them to the strategies used by these other organisms to perceive their own morphology.
Keywords
Cell Cycle/physiology, Models, Biological, Morphogenesis/physiology, Protein-Serine-Threonine Kinases/physiology, Schizosaccharomyces/cytology, Schizosaccharomyces pombe Proteins/physiology, Species Specificity
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2010 10:20
Last modification date
20/08/2019 14:54