MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models.

Details

Serval ID
serval:BIB_90EE6DBB970E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models.
Journal
Analytical biochemistry
Author(s)
Lanz B., Rackayova V., Braissant O., Cudalbu C.
ISSN
1096-0309 (Electronic)
ISSN-L
0003-2697
Publication state
Published
Issued date
15/07/2017
Peer-reviewed
Oui
Volume
529
Pages
245-269
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, an important biochemical pathway in excitatory neurotransmission, analyzed using in vivo MRS of different accessible nuclei: (1)H, (13)C, (15)N and (31)P. The different methodological aspects of data acquisition, processing and absolute quantification of the MRS data for each nucleus will be presented, as well as the description of the mathematical modeling approach to interpret the MRS measurements in terms of biochemical kinetics. The unique advantages of MRS, especially its non-invasive nature enabling longitudinal monitoring of brain disease progression and/or effect of treatment is illustrated in the particular context of hyperammonemic disorders with a specific focus on animal models. We review the current possibilities given by in vivo MRS to investigate some of the molecular mechanisms involved in hyperammonemic disorders and to give a better understanding of the process of development of hepatic encephalopathy, a severe neuropsychiatric disorder that frequently accompanies liver disease.

Keywords
Animals, Brain/metabolism, Glutamic Acid/metabolism, Glutamine/metabolism, Hyperammonemia/diagnosis, Hyperammonemia/metabolism, Magnetic Resonance Imaging/methods, Magnetic Resonance Spectroscopy/methods, Models, Biological, Rats, Brain metabolism, Glutamate/glutamine cycle, Hyperammonemia, In vivo magnetic resonance spectroscopy, Neuroenergetics
Pubmed
Web of science
Create date
10/07/2017 15:33
Last modification date
03/03/2018 19:26
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