EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases.

Details

Serval ID
serval:BIB_8FB242E2045E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases.
Journal
EJNMMI research
Author(s)
Aarntzen EHJG, Noriega-Álvarez E., Artiko V., Dias A.H., Gheysens O., Glaudemans AWJM, Lauri C., Treglia G., van den Wyngaert T., van Leeuwen FWB, Terry SYA
ISSN
2191-219X (Print)
ISSN-L
2191-219X
Publication state
Published
Issued date
06/09/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
85
Language
english
Notes
Publication types: Letter
Publication Status: epublish
Abstract
Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the pathogenesis of inflammatory musculoskeletal diseases is, to a large extent, derived from preclinical and basic research experiments. In vivo molecular imaging enables us to study molecular targets and to measure biochemical processes non-invasively and longitudinally, providing information on disease processes and potential therapeutic strategies, e.g. efficacy of novel therapeutic interventions, which is of complementary value next to ex vivo (post mortem) histopathological analysis and molecular assays. Remarkably, the large body of preclinical imaging studies in inflammatory musculoskeletal disease is in contrast with the limited reports on molecular imaging in clinical practice and clinical guidelines. Therefore, in this EANM-endorsed position paper, we performed a systematic review of the preclinical studies in inflammatory musculoskeletal diseases that involve radionuclide imaging, with a detailed description of the animal models used. From these reflections, we provide recommendations on what future studies in this field should encompass to facilitate a greater impact of radionuclide imaging techniques on the translation to clinical settings.
Keywords
Inflammatory musculoskeletal disease, Molecular imaging, Positron emission tomography, Preclinical, Rheumatoid disease, Single photon emission computed tomography
Pubmed
Web of science
Open Access
Yes
Create date
24/09/2021 16:36
Last modification date
16/12/2021 6:33
Usage data