Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour

Details

Serval ID
serval:BIB_8F8CBDA5F1D7
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour
Journal
Acta Endocrinologica
Author(s)
Maye  P., Bisetti  A., Burger  A., Docter  R., Gaillard  R., Griessen  M., Pelte  M. F.
ISSN
0001-5598 (Print)
Publication state
Published
Issued date
01/1989
Volume
120
Number
1
Pages
87-91
Notes
Case Reports
Journal Article --- Old month value: Jan
Abstract
Prealbumin, one of the main thyroxine transport proteins, has recently been shown to be a valuable immunohistochemical marker of neuroendocrine tumours. We report the case of a multisecretory pancreatic endocrine tumour whose prealbumin secretion was so high that it produced a peak on routine serum protein electrophoresis and induced a euthyroid hyperthyroxinemia. The maximal binding capacity of prealbumin for thyroxine was indeed markedly increased, whereas its affinity for this hormone was normal. The tumour was associated with gastric hyperacidity and hypergastrinemia thereby evoking a Zollinger-Ellison syndrome. The secretin stimulation test and gastrin tumoural immunohistochemistry were, however, negative. We suggest that the concomitant tumoural production of gastrin-releasing peptide was responsible for the gastric hyperacidity and hypergastrinemia. This hormone probably also accounted for a moderate hypercorticism.
Keywords
Adrenocortical Hyperfunction/*complications Gastrins/blood Humans Hyperthyroxinemia/*complications Immunoenzyme Techniques Male Middle Aged Multiple Endocrine Neoplasia/*complications/metabolism Pancreatic Neoplasms/*complications/metabolism Prealbumin/*analysis Thyroxine-Binding Proteins/analysis Zollinger-Ellison Syndrome/*complications
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 14:53
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