Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour
Détails
ID Serval
serval:BIB_8F8CBDA5F1D7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour
Périodique
Acta Endocrinologica
ISSN
0001-5598 (Print)
Statut éditorial
Publié
Date de publication
01/1989
Volume
120
Numéro
1
Pages
87-91
Notes
Case Reports
Journal Article --- Old month value: Jan
Journal Article --- Old month value: Jan
Résumé
Prealbumin, one of the main thyroxine transport proteins, has recently been shown to be a valuable immunohistochemical marker of neuroendocrine tumours. We report the case of a multisecretory pancreatic endocrine tumour whose prealbumin secretion was so high that it produced a peak on routine serum protein electrophoresis and induced a euthyroid hyperthyroxinemia. The maximal binding capacity of prealbumin for thyroxine was indeed markedly increased, whereas its affinity for this hormone was normal. The tumour was associated with gastric hyperacidity and hypergastrinemia thereby evoking a Zollinger-Ellison syndrome. The secretin stimulation test and gastrin tumoural immunohistochemistry were, however, negative. We suggest that the concomitant tumoural production of gastrin-releasing peptide was responsible for the gastric hyperacidity and hypergastrinemia. This hormone probably also accounted for a moderate hypercorticism.
Mots-clé
Adrenocortical Hyperfunction/*complications
Gastrins/blood
Humans
Hyperthyroxinemia/*complications
Immunoenzyme Techniques
Male
Middle Aged
Multiple Endocrine Neoplasia/*complications/metabolism
Pancreatic Neoplasms/*complications/metabolism
Prealbumin/*analysis
Thyroxine-Binding Proteins/analysis
Zollinger-Ellison Syndrome/*complications
Pubmed
Web of science
Création de la notice
15/02/2008 17:57
Dernière modification de la notice
20/08/2019 15:53