Influenza vaccination in the face of immune exhaustion: Is herd immunity effective for protecting the elderly?

Details

Serval ID
serval:BIB_8F2B64845B58
Type
Article: article from journal or magazin.
Collection
Publications
Title
Influenza vaccination in the face of immune exhaustion: Is herd immunity effective for protecting the elderly?
Journal
Influenza Research and Treatment
Author(s)
Lang PO, Samaras D, Samaras N, Govind S, Aspinall R.
ISSN
2090-1380
ISSN-L
2090-1399
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
2011
Number
419216
Pages
1-8
Language
english
Notes
pdf: Review Article
Abstract
At the start of the 21st century, seasonal influenza virus infection is still a major public health concern across the world. The recent body of evidence confirms that trivalent inactivated influenza vaccines (TIVs) are not optimal within the population who account for approximately 90% of all influenza-related death: elderly and chronically ill individuals regardless of age. With the ever increasing aging of the world population and the recent fears of any pandemic influenza rife, great efforts and resources have been dedicated to developing more immunogenic vaccines and strategies for enhancing protection in these higher-risk groups. This paper describes the mechanisms that shape immune response at the extreme ages of life and how they have been taken into account to design more effective immunization strategies for these vulnerable populations. Furthermore, consideration will be given to how herd immunity may provide an effective strategy in preventing the burden of seasonal influenza infection within the aged population.
Open Access
Yes
Create date
15/04/2015 9:27
Last modification date
20/08/2019 14:52
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