Backseat drivers: the hidden influence of microbial viruses on disease.

Details

Serval ID
serval:BIB_8EBB90AB458E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Backseat drivers: the hidden influence of microbial viruses on disease.
Journal
Current Opinion in Microbiology
Author(s)
Hartley M.A., Ronet C., Fasel N.
ISSN
1879-0364 (Electronic)
ISSN-L
1369-5274
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
15
Number
4
Pages
538-545
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication WOS Document Type: Review
Abstract
Because viral replication depends on the vigour of its host, many viruses have evolved incentives of fitness to pay their keep. When the viral host is a human pathogen, these fitness factors can surface as virulence: creating a Russian doll of pathogenesis where pathogens within pathogens complicate the disease process. Microbial viruses can even be independently immunogenic, as we recently reported for leishmania-virus. Thus, the incidence of this 'hyperpathogenism' is becoming an important clinical consideration and by appreciating the microbial-virus as a backseat driver of human disease, we could exploit its presence as a diagnostic biomarker and molecular target for therapeutic intervention. Here we discuss the prevalence of clinically relevant hyperpathogenism as well as the environmental sanctuaries that breed it.
Pubmed
Web of science
Create date
26/10/2012 19:26
Last modification date
20/08/2019 15:52
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