ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.

Details

Serval ID
serval:BIB_8E8213483E10
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.
Journal
Cell reports
Author(s)
Fougerat A., Schoiswohl G., Polizzi A., Régnier M., Wagner C., Smati S., Fougeray T., Lippi Y., Lasserre F., Raho I., Melin V., Tramunt B., Métivier R., Sommer C., Benhamed F., Alkhoury C., Greulich F., Jouffe C., Emile A., Schupp M., Gourdy P., Dubot P., Levade T., Meynard D., Ellero-Simatos S., Gamet-Payrastre L., Panasyuk G., Uhlenhaut H., Amri E.Z., Cruciani-Guglielmacci C., Postic C., Wahli W., Loiseau N., Montagner A., Langin D., Lass A., Guillou H.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
07/06/2022
Peer-reviewed
Oui
Volume
39
Number
10
Pages
110910
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a genomic and metabolic response required for homeostasis during fasting. This includes the biosynthesis of ketone bodies and of fibroblast growth factor 21 (FGF21). Here we show that in the absence of adipose triglyceride lipase (ATGL) in adipocytes, ketone body and FGF21 production is impaired upon fasting. Liver gene expression analysis highlights a set of fasting-induced genes sensitive to both ATGL deletion in adipocytes and PPARα deletion in hepatocytes. Adipose tissue lipolysis induced by activation of the β <sub>3</sub> -adrenergic receptor also triggers such PPARα-dependent responses not only in the liver but also in brown adipose tissue (BAT). Intact PPARα activity in hepatocytes is required for the cross-talk between adipose tissues and the liver during fat mobilization.
Keywords
Adipose Tissue/metabolism, Adipose Tissue, Brown/metabolism, Adipose Tissue, White/metabolism, Hepatocytes/metabolism, Ketone Bodies/metabolism, Lipolysis/physiology, PPAR alpha/metabolism, ATGL, CP: Metabolism, FGF21, PPARα, fasting, ketogenesis, lipolysis
Pubmed
Open Access
Yes
Create date
21/06/2022 14:19
Last modification date
24/06/2022 6:38
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