Markedly reduced blood pressure responsiveness in endotoxemic rats; reversal by neuropeptide Y.

Details

Serval ID
serval:BIB_8E74F2DE1946
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Markedly reduced blood pressure responsiveness in endotoxemic rats; reversal by neuropeptide Y.
Journal
Life sciences
Author(s)
Evéquoz D., Waeber B., Corder R., Nussberger J., Gaillard R., Brunner H.R.
ISSN
0024-3205
Publication state
Published
Issued date
1987
Peer-reviewed
Oui
Volume
41
Number
23
Pages
2573-80
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia. NPY and endotoxin were infused at doses which had no effect on blood pressure, whether given alone or in combination. Endotoxin markedly reduced the pressor responses to bolus injections of norepinephrine. However, blood pressure responsiveness could be enhanced by infusing NPY simultaneously with the endotoxin. It is suggested that low dose NPY infusions may be clinically useful in reversing the reduced vascular responsiveness to pressor amines in shock.
Keywords
Adrenal Medulla, Animals, Blood Pressure, Dose-Response Relationship, Drug, Endotoxins, Infusions, Intravenous, Male, Neuropeptide Y, Norepinephrine, Rats, Rats, Inbred Strains, Sepsis
Pubmed
Web of science
Create date
05/03/2008 17:40
Last modification date
20/08/2019 15:52
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