Glomerular filtration rate: measure creatinine and height rather than cystatin C!

Details

Serval ID
serval:BIB_8E5626D35E54
Type
Article: article from journal or magazin.
Collection
Publications
Title
Glomerular filtration rate: measure creatinine and height rather than cystatin C!
Journal
Acta Paediatrica
Author(s)
Martini S., Prévot A., Mosig D., Werner D., van Melle G., Guignard J.P.
ISSN
0803-5253
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
92
Number
9
Pages
1052-1057
Language
english
Abstract
AIM: Inulin clearance (Cin) is the gold standard for assessing glomerular filtration rate (GFR). Other methods are based on the plasma creatinine concentration (Pcreat), creatinine clearance (Ccreat), the Haycock-Schwartz formula and the plasma concentration of cystatin C (PcysC), a 13 kDa basic protein produced at a constant rate by all nucleated cells. The present prospective study was thus designed to evaluate the reliability of PcysC as a marker of GFR in comparison with that of Pcreat, Ccreat and the Haycock-Schwartz formula, using Cin as the gold standard. METHODS: Ninety-nine children (51 m/48 f), with a median age of 8.3 y (1.0-17.9) were studied. Using a cut-off for Cin of 100 ml/min per 1.73 m2, 54 children (54.5%) had impaired GFR. Those with normal GFR were comparable for age, height, weight and body mass index. RESULTS: Logistic regression, ROC analysis and linear regression all showed that Ccreat was the best parameter to discriminate between impaired and normal GFR, followed by the Haycock-Schwartz formula, PcysC, and finally Pcreat, each one being significantly more predictive than the next. CONCLUSION: GFR is better assessed by the Haycock-Schwartz formula than by PcysC or Pcreat alone. It is therefore concluded that when urine collection is not possible, simply measuring the child's Pcreat and height is the best, easiest and cheapest way to assess GFR.
Keywords
Adolescent, Body Height, Child, Child, Preschool, Creatinine/blood, Creatinine/urine, Cystatin C, Cystatins/blood, Female, Glomerular Filtration Rate, Humans, Infant, Inulin/blood, Inulin/urine, Male
Pubmed
Web of science
Create date
20/07/2009 14:12
Last modification date
03/03/2018 19:18
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