Altered sensory processing in the somatosensory cortex of the mouse mutant barrelless

Details

Serval ID
serval:BIB_8E14D2E8C9EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Altered sensory processing in the somatosensory cortex of the mouse mutant barrelless
Journal
Science
Author(s)
Welker  E., Armstrong-James  M., Bronchti  G., Ourednik  W., Gheorghita-Baechler  F., Dubois  R., Guernsey  D. L., Van der Loos  H., Neumann  P. E.
ISSN
0036-8075 (Print)
Publication state
Published
Issued date
03/1996
Volume
271
Number
5257
Pages
1864-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 29
Abstract
Mice homozygous for the barrelless (brl) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed "barrels" in the primary somatosensory cortex. Deoxyglucose uptake demonstrated that the topology of the cortical whisker representation is nevertheless preserved. Anterograde tracers revealed a lack of spatial segregation of thalamic afferents into individual barrel territories, and single-cell recordings demonstrated a lack of temporal discrimination of center from surround information. Thus, structural segregation of thalamic inputs is not essential to generate topological order in the somatosensory cortex, but it is required for discrete spatiotemporal relay of sensory information to the cortex.
Keywords
Animals Axons/ultrastructure Brain/cytology/metabolism Chromosome Mapping Deoxyglucose/metabolism Mice Mice, Mutant Strains Neural Pathways Neurons/cytology/physiology Phenotype Somatosensory Cortex/cytology/metabolism/*physiology Thalamus/cytology/physiology Vibrissae/*innervation/physiology
Pubmed
Web of science
Create date
24/01/2008 14:40
Last modification date
20/08/2019 14:52
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