Altered sensory processing in the somatosensory cortex of the mouse mutant barrelless
Détails
ID Serval
serval:BIB_8E14D2E8C9EF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Altered sensory processing in the somatosensory cortex of the mouse mutant barrelless
Périodique
Science
ISSN
0036-8075 (Print)
Statut éditorial
Publié
Date de publication
03/1996
Volume
271
Numéro
5257
Pages
1864-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 29
Research Support, Non-U.S. Gov't --- Old month value: Mar 29
Résumé
Mice homozygous for the barrelless (brl) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed "barrels" in the primary somatosensory cortex. Deoxyglucose uptake demonstrated that the topology of the cortical whisker representation is nevertheless preserved. Anterograde tracers revealed a lack of spatial segregation of thalamic afferents into individual barrel territories, and single-cell recordings demonstrated a lack of temporal discrimination of center from surround information. Thus, structural segregation of thalamic inputs is not essential to generate topological order in the somatosensory cortex, but it is required for discrete spatiotemporal relay of sensory information to the cortex.
Mots-clé
Animals
Axons/ultrastructure
Brain/cytology/metabolism
Chromosome Mapping
Deoxyglucose/metabolism
Mice
Mice, Mutant Strains
Neural Pathways
Neurons/cytology/physiology
Phenotype
Somatosensory Cortex/cytology/metabolism/*physiology
Thalamus/cytology/physiology
Vibrissae/*innervation/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 15:40
Dernière modification de la notice
20/08/2019 15:52