Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding.

Details

Serval ID
serval:BIB_8DF52D941B9D
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding.
Journal
Journal of Investigative Dermatology
Author(s)
Stamenkovic I., Yu Q.
ISSN
1523-1747[electronic]
Publication state
Published
Issued date
2009
Volume
129
Number
6
Pages
1321-1324
Language
english
Abstract
CD44 is the major cell-surface receptor for hyaluronan, which is implicated in cell-cell and cell-matrix adhesion, cell migration, and signaling. Studies have shown that CD44-dependent migration requires CD44 to be shed from the cell surface and that matrix metalloproteinase-mediated cleavage may provide an underlying mechanism. However, the full spectrum of proteases that may participate in CD44 shedding has yet to be defined. In this issue, Anderegg et al. demonstrate that ADAM10, but not ADAM17 or MMP14, mediates constitutive shedding of CD44 in human melanoma cells and that knockdown of ADAM10 blocks the antiproliferative activity of the soluble proteolytic cleavage product of CD44.
Keywords
ADAM Proteins/metabolism, Amyloid Precursor Protein Secretases/metabolism, Antigens, CD44/biosynthesis, Antigens, CD44/physiology, Cell Adhesion, Cell Line, Tumor, Cell Membrane/metabolism, Gene Expression Regulation, Humans, Hyaluronic Acid/metabolism, Matrix Metalloproteinase 14/metabolism, Matrix Metalloproteinases/metabolism, Membrane Proteins/metabolism, Models, Biological, Neoplasms/therapy, Neoplastic Stem Cells/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
02/09/2009 8:05
Last modification date
20/08/2019 14:51
Usage data