Various human interferon alpha subclasses cross-react with common receptors: their binding affinities correlate with their specific biological activities.
Details
Serval ID
serval:BIB_8C26BCAFB500
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Various human interferon alpha subclasses cross-react with common receptors: their binding affinities correlate with their specific biological activities.
Journal
Virology
ISSN
0042-6822 (Print)
ISSN-L
0042-6822
Publication state
Published
Issued date
1984
Volume
132
Number
1
Pages
211-216
Language
english
Abstract
Seven different human interferon (IFN) alpha subtypes were compared with regard to competitive inhibition of specific high-affinity binding of 125I-labeled IFN alpha-2 to human and bovine cells. All IFNs tested (alpha-1, -2, -4, -5, -6, -7, -8) competed for common binding sites. Marked differences in the binding affinities were observed between IFN alpha-1 and IFN alpha-2. The binding affinities of the various subtypes correlated with the respective specific biological activities determined in an antiviral assay. These observations suggest that at least some biological effects of IFNs are initiated by receptor activation and depend quantitatively on the degree of receptor saturation.
Keywords
Animals, Binding, Competitive, Cattle, Female, Humans, Interferon Type I/metabolism, Pregnancy, Receptors, Cell Surface/metabolism, Receptors, Interferon
Pubmed
Web of science
Create date
28/01/2008 12:36
Last modification date
20/08/2019 15:50
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