Evolution of white matter tract microstructure across the life span.

Details

Serval ID
serval:BIB_89DBF4956A87
Type
Article: article from journal or magazin.
Collection
Publications
Title
Evolution of white matter tract microstructure across the life span.
Journal
Human brain mapping
Author(s)
Slater D.A., Melie-Garcia L., Preisig M., Kherif F., Lutti A., Draganski B.
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Publication state
Published
Issued date
05/2019
Peer-reviewed
Oui
Volume
40
Number
7
Pages
2252-2268
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The human brain undergoes dramatic structural change over the life span. In a large imaging cohort of 801 individuals aged 7-84 years, we applied quantitative relaxometry and diffusion microstructure imaging in combination with diffusion tractography to investigate tissue property dynamics across the human life span. Significant nonlinear aging effects were consistently observed across tracts and tissue measures. The age at which white matter (WM) fascicles attain peak maturation varies substantially across tissue measurements and tracts. These observations of heterochronicity and spatial heterogeneity of tract maturation highlight the importance of using multiple tissue measurements to investigate each region of the WM. Our data further provide additional quantitative evidence in support of the last-in-first-out retrogenesis hypothesis of aging, demonstrating a strong correlational relationship between peak maturational timing and the extent of quadratic measurement differences across the life span for the most myelin sensitive measures. These findings present an important baseline from which to assess divergence from normative aging trends in developmental and degenerative disorders, and to further investigate the mechanisms connecting WM microstructure to cognition.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Brain/diagnostic imaging, Brain/physiology, Child, Diffusion Tensor Imaging/trends, Female, Humans, Longevity/physiology, Male, Middle Aged, White Matter/diagnostic imaging, White Matter/physiology, Young Adult, MRI, aging, degeneration, development, intracellular volume fraction (ICVF), iron, life span, longitudinal (R1) and transverse (R2*) relaxation rates, mean diffusivity (MD), myelin, quantitative magnetic resonance imaging (qMRI), tractography, white matter
Pubmed
Web of science
Open Access
Yes
Create date
31/01/2019 10:19
Last modification date
27/04/2020 6:20
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