Corticosteroid-responsive postmalaria encephalopathy characterized by motor aphasia, myoclonus, and postural tremor

Details

Serval ID
serval:BIB_8990CEBB1BD8
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Corticosteroid-responsive postmalaria encephalopathy characterized by motor aphasia, myoclonus, and postural tremor
Journal
Archives of Neurology
Author(s)
Schnorf  H., Diserens  K., Schnyder  H., Chofflon  M., Loutan  L., Chaves  V., Landis  T.
ISSN
0003-9942 (Print)
Publication state
Published
Issued date
03/1998
Volume
55
Number
3
Pages
417-20
Notes
Case Reports
Journal Article --- Old month value: Mar
Abstract
OBJECTIVES: To study the clinical spectrum of an acute severe encephalopathy occurring in 2 patients after recovery from falciparum malaria infection and to compare it with the reported clinical features of the postmalaria neurological syndrome. DESIGN: Case report. SETTING: Tertiary care hospital. PATIENTS: Two patients presented with acute onset of fluctuating motor aphasia, severe generalized myoclonus, and postural tremor. Additional signs were cerebellar ataxia, and in 1 patient, generalized epileptic seizures. Magnetic resonance imaging of the brain revealed patchy white matter lesions in 1 patient. Clinically, the patients' conditions continued to worsen until corticosteroids were introduced, the use of which induced a rapid, albeit incomplete, recovery. CONCLUSIONS: We describe a new, severe variant of the still poorly defined postmalaria neurological syndrome. We propose a preliminary classification of this syndrome, according to its clinical characteristics, as follows: a mild or localized form, characterized by isolated cerebellar ataxia or postural tremor; a diffuse, but relatively mild encephalopathic form, characterized by acute confusion or epileptic seizures; and a severe, corticosteroid-responsive encephalopathy that is characterized by motor aphasia, generalized myoclonus, postural tremor, and cerebellar ataxia.
Keywords
Adrenal Cortex Hormones/administration & dosage Adult Aphasia/*etiology Female Humans Malaria, Cerebral/*complications/drug therapy Male Middle Aged Myoclonus/*etiology Posture Tremor/*etiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:42
Last modification date
20/08/2019 15:48
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