Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland.

Details

Ressource 1Download: serval:BIB_87B599DDBECC.P001 (126.20 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_87B599DDBECC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland.
Journal
European Journal of Pediatrics
Author(s)
Laubscher B., Bänziger O., Schubiger G.
Working group(s)
Swiss Paediatric Surveillance Unit (SPSU)
Contributor(s)
Aebi Ch., Antonelli E., Bär W., Bianchetti M., Blumberg A., Bucher H., Buetti L., Cachat F., Carrel O., Cattin P., Corboz A., Däster C., Diebold P., Dolivo P., Farron F., Fluri S., Gebauer M., Gehri M., Giannoni E., Haenggeli C., Hodel M., Hüppi P., Imahorn P., Irion O., Kind C., Kistler W., Knöpfli B., Kottanattu L., Lapaire O., Laubscher B., Leuthardt R., Lips U., Malzacher A., Dougall J., Meyer P., Micheli JL., Minet JC., Mönkhoff M., Neuhaus T., Pezzoli V., Piol N., Posfay Barbe K., Reinhard L., Renevey F., Roten H., Rudin C., Schlumbom V., Sizonenko S., Stirnemann S., Stocker S., Stüssi C., Tabin R., Terrier P., Villiger R., Wellmann S., Wildhaber J., Wopmann M., Zeilinger G., Zemmouri A., Zimmermann U.
ISSN
1432-1076 (Electronic)
ISSN-L
0340-6199
Publication state
Published
Issued date
2013
Volume
172
Number
3
Pages
357-360
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Original article
Abstract
In 2003, the Swiss guidelines to prevent vitamin K deficiency bleeding (VKDB) were adapted. As two oral doses (2 mg, hour/day 4) of mixed micellar VK preparation had failed to abolish late VKDB, a third dose (week 4) was introduced. This report summarizes the new guidelines acceptance by Swiss pediatricians and the results of a prospective 6-year surveillance to study their influence on the incidence of VKDB. The new guidelines acceptance by Swiss pediatricians was evaluated by a questionnaire sent to all pediatricians of the Swiss Society of Paediatrics. With the help of the Swiss Paediatric Surveillance Unit, the incidence of VKDB was monitored prospectively from July 1, 2005 until June 30, 2011. Over a 6-year period (458,184 live births), there was one case of early and four cases of late VKDB. Overall incidence was 1.09/10(5) (95 % confidence intervals (CI) 0.4-2.6). Late VKDB incidence was 0.87/10(5) (95 % CI 0.24-2.24). All four infants with late VKDB had an undiagnosed cholestasis at the time of bleeding; parents of 3/4 had refused VK prophylaxis, and in 1/4, the third VK dose had been forgotten. Compared with historical control who had received only two oral doses of mixed micellar VK (18 cases for 475,372 live births), the incidence of late VKDB was significantly lower with three oral doses (Chi(2),Yates correction, P = 0.007). CONCLUSION: VKDB prophylaxis with 3 × 2 mg oral doses of mixed micellar VK seems to prevent adequately infants from VKDB. The main risk factors for VKDB in breast-fed infants are parental VK prophylaxis refusal or an unknown cholestasis.
Pubmed
Web of science
Open Access
Yes
Create date
12/04/2013 17:47
Last modification date
01/10/2019 6:18
Usage data