Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland.

Détails

ID Serval
serval:BIB_87B599DDBECC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland.
Périodique
European Journal of Pediatrics
Auteur(s)
Laubscher B., Bänziger O., Schubiger G.
Collaborateur(s)
Swiss Paediatric Surveillance Unit (SPSU)
Contributeur(s)
Aebi Ch., Antonelli E., Bär W., Bianchetti M., Blumberg A., Bucher H., Buetti L., Cachat F., Carrel O., Cattin P., Corboz A., Däster C., Diebold P., Dolivo P., Farron F., Fluri S., Gebauer M., Gehri M., Giannoni E., Haenggeli C., Hodel M., Hüppi P., Imahorn P., Irion O., Kind C., Kistler W., Knöpfli B., Kottanattu L., Lapaire O., Laubscher B., Leuthardt R., Lips U., Malzacher A., Dougall J., Meyer P., Micheli JL., Minet JC., Mönkhoff M., Neuhaus T., Pezzoli V., Piol N., Posfay Barbe K., Reinhard L., Renevey F., Roten H., Rudin C., Schlumbom V., Sizonenko S., Stirnemann S., Stocker S., Stüssi C., Tabin R., Terrier P., Villiger R., Wellmann S., Wildhaber J., Wopmann M., Zeilinger G., Zemmouri A., Zimmermann U.
ISSN
1432-1076 (Electronic)
ISSN-L
0340-6199
Statut éditorial
Publié
Date de publication
2013
Volume
172
Numéro
3
Pages
357-360
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Original article
Résumé
In 2003, the Swiss guidelines to prevent vitamin K deficiency bleeding (VKDB) were adapted. As two oral doses (2 mg, hour/day 4) of mixed micellar VK preparation had failed to abolish late VKDB, a third dose (week 4) was introduced. This report summarizes the new guidelines acceptance by Swiss pediatricians and the results of a prospective 6-year surveillance to study their influence on the incidence of VKDB. The new guidelines acceptance by Swiss pediatricians was evaluated by a questionnaire sent to all pediatricians of the Swiss Society of Paediatrics. With the help of the Swiss Paediatric Surveillance Unit, the incidence of VKDB was monitored prospectively from July 1, 2005 until June 30, 2011. Over a 6-year period (458,184 live births), there was one case of early and four cases of late VKDB. Overall incidence was 1.09/10(5) (95 % confidence intervals (CI) 0.4-2.6). Late VKDB incidence was 0.87/10(5) (95 % CI 0.24-2.24). All four infants with late VKDB had an undiagnosed cholestasis at the time of bleeding; parents of 3/4 had refused VK prophylaxis, and in 1/4, the third VK dose had been forgotten. Compared with historical control who had received only two oral doses of mixed micellar VK (18 cases for 475,372 live births), the incidence of late VKDB was significantly lower with three oral doses (Chi(2),Yates correction, P = 0.007). CONCLUSION: VKDB prophylaxis with 3 × 2 mg oral doses of mixed micellar VK seems to prevent adequately infants from VKDB. The main risk factors for VKDB in breast-fed infants are parental VK prophylaxis refusal or an unknown cholestasis.
Pubmed
Web of science
Création de la notice
12/04/2013 18:47
Dernière modification de la notice
03/03/2018 19:02
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