BAFF AND APRIL: a tutorial on B cell survival.

Details

Serval ID
serval:BIB_877D5CD8B79B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
BAFF AND APRIL: a tutorial on B cell survival.
Journal
Annual Review of Immunology
Author(s)
Mackay F., Schneider P., Rennert P., Browning J.
ISSN
0732-0582 (Print)
ISSN-L
0732-0582
Publication state
Published
Issued date
2003
Volume
21
Pages
231-264
Language
english
Abstract
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
Keywords
Animals, Autoimmunity, B-Cell Activating Factor, B-Cell Activation Factor Receptor, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Cell Survival, Disease Models, Animal, Humans, Immune Tolerance, Immunoglobulin A/metabolism, Ligands, Membrane Proteins/chemistry, Membrane Proteins/genetics, Mice, Mice, Transgenic, Receptors, Tumor Necrosis Factor/chemistry, Receptors, Tumor Necrosis Factor/genetics, Signal Transduction, Tumor Necrosis Factor Ligand Superfamily Member 13, Tumor Necrosis Factor-alpha/chemistry, Tumor Necrosis Factor-alpha/genetics
Pubmed
Web of science
Create date
19/01/2008 17:30
Last modification date
20/08/2019 14:46
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