How to master the host immune system? Leishmania parasites have the solutions!

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State: Public
Version: Final published version
Serval ID
serval:BIB_8774637093C2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
How to master the host immune system? Leishmania parasites have the solutions!
Journal
International immunology
Author(s)
Rossi M., Fasel N.
ISSN
1460-2377 (Electronic)
ISSN-L
0953-8178
Publication state
Published
Issued date
10/03/2018
Peer-reviewed
Oui
Volume
30
Number
3
Pages
103-111
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide. Leishmaniasis can have very different outcomes ranging from cutaneous lesions, mucosal lesions to visceralization depending on the species of the infecting parasite and on the immune response developed by the host. As an obligate intracellular parasite, residing within macrophages, Leishmania evolved in strict contact with the host immune system, developing different mechanisms to evade or modulate the immune response. Various types of immune responses are observed during different Leishmania spp. infections, resulting in parasite clearance but also contributing to the pathogenesis, thus increasing the complexity of the course of the disease. Interestingly, depending on the type of leishmaniasis developed, opposite treatment strategies, which either boost or inhibit the inflammatory response, have shown efficacy. In this review, we summarize the contribution of different immune cell types to the development of the anti-leishmanial immune response and the parasite strategies to evade and modulate host immunity. Further, we discuss the involvement of co-infecting pathogens in the determination of the outcome of leishmaniasis and on the effectiveness of treatment and the implication of the immune response for treatment and vaccine development.
Keywords
Animals, Humans, Leishmania/immunology, Leishmaniasis/immunology, Leishmaniasis/parasitology, Leishmaniasis Vaccines/immunology
Pubmed
Web of science
Open Access
Yes
Create date
12/01/2018 9:09
Last modification date
20/08/2019 15:46
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