Methodology of H NMR Spectroscopy of the Human Brain at Very High Magnetic Fields.

Details

Serval ID
serval:BIB_8731B84C8BA0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Methodology of H NMR Spectroscopy of the Human Brain at Very High Magnetic Fields.
Journal
Applied Magnetic Resonance
Author(s)
Tkáč I., Gruetter R.
ISSN
0937-9347 (Print)
ISSN-L
0937-9347
Publication state
Published
Issued date
2005
Volume
29
Number
1
Pages
139-157
Language
english
Notes
Publication types: JOURNAL ARTICLEPublication Status: ppublish
Abstract
An ultrashort-echo-time stimulated echo-acquisition mode (STEAM) pulse sequence with interleaved outer volume suppression and VAPOR (variable power and optimized relaxation delays) water suppression was redesigned and optimized for human applications at 4 and 7 T, taking into account the specific requirements for spectroscopy at high magnetic fields and limitations of currently available hardware. In combination with automatic shimming, automated parameter adjustments and data processing, this method provided a user-friendly tool for routine (1)H nuclear magnetic resonance (NMR) spectroscopy of the human brain at very high magnetic fields. Effects of first- and second-order shimming, single-scan averaging, frequency and phase corrections, and eddy currents were described. LCModel analysis of an in vivo (1)H NMR spectrum measured from the human brain at 7 T allowed reliable quantification of more than fifteen metabolites noninvasively, illustrating the potential of high-field NMR spectroscopy. Examples of spectroscopic studies performed at 4 and 7 T demonstrated the high reproducibility of acquired spectra quality.
Pubmed
Web of science
Create date
04/08/2010 15:28
Last modification date
20/08/2019 14:46
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