Determination of amitriptyline in the hair of psychiatric patients.
Details
Serval ID
serval:BIB_86D8BB32720F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Determination of amitriptyline in the hair of psychiatric patients.
Journal
Human and Experimental Toxicology
ISSN
0960-3271[print], 0960-3271[linking]
Publication state
Published
Issued date
1992
Volume
11
Number
5
Pages
363-367
Language
english
Abstract
A study was conducted on 60 psychiatric patients to evaluate the reliability of a drug-exposure screening test based on gas chromatography/mass spectrometry analysis of hair samples for amitriptyline, and the possibility of using the hair concentrations of amitriptyline to monitor patients' therapeutic compliance. The qualitative test was found to be very reliable (sensitivity 93.3%; specificity 100%; positive and negative predictive values 100 and 93.8%) in assessing the consumer status of patients over a period of 2 months before analysis. Hair levels of amitriptyline ranged from 0 to 17.21 ng mg-1. A significant relationship (r = 0.563; P < 0.002) was found between the hair concentrations and the cumulative intake of amitriptyline over the studied period, but was not judged close enough to estimate one individual's therapeutic compliance. The results are discussed in the light of existing literature.
Keywords
Adolescent, Adult, Aged, Amitriptyline/administration & dosage, Amitriptyline/analysis, Female, Hair/chemistry, Humans, Male, Mental Disorders/metabolism, Middle Aged
Pubmed
Create date
18/10/2010 14:57
Last modification date
20/08/2019 15:46