What we would like to know about the antihypertensive mechanisms of angiotensin converting enzyme inhibition

Details

Serval ID
serval:BIB_86B5DDE08C5D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
What we would like to know about the antihypertensive mechanisms of angiotensin converting enzyme inhibition
Journal
Journal of Hypertension. Supplement
Author(s)
Brunner  H. R., Waeber  B., Nussberger  J.
ISSN
0952-1178 (Print)
Publication state
Published
Issued date
12/1988
Volume
6
Number
3
Pages
S1-5
Notes
Journal Article
Review --- Old month value: Dec
Abstract
Angiotensin converting enzyme (ACE) inhibitors induce haemodynamic, humoral and metabolic actions which have been well characterized during the last decade. The precise mechanisms involved in these actions still need clarification. Among the many questions we need answered are the following: under steady-state conditions, does plasma ACE activity reflect angiotensin I conversion in tissues? Do the low levels of angiotensin II observed after ACE inhibition still contribute to vascular tone? What is the precise role of extrarenal tissue renin in the regulation of vascular tone? What is the role of bradykinin, prostaglandins and the interaction with the sympathetic nervous system in the antihypertensive effect of ACE inhibition? We hope that definite answers to these questions will be found during the second decade of the use of ACE inhibitors.
Keywords
Angiotensin-Converting Enzyme Inhibitors/*pharmacology Animals Blood Pressure/*drug effects Bradykinin/pharmacology Dinoprostone/metabolism Humans Renin-Angiotensin System/drug effects Sympathetic Nervous System/drug effects/physiology
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 14:46
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