From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.

Details

Serval ID
serval:BIB_867ED9E568B7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.
Journal
The Journal of investigative dermatology
Author(s)
Arkin L.M., Moon J.J., Tran J.M., Asgari S., O'Farrelly C., Casanova J.L., Cowen E.W., Mays J.W., Singh A.M., Drolet B.A.
Working group(s)
COVID Human Genetic Effort
Contributor(s)
Aiuti A., Belot A., Bolze A., Bondarenko A., Sediva A., Shcherbina A., Planas A.M., Condino-Neto A., Pujol A., Drolet B.A., Catherine B., Flores C., Rodríguez-Gallego C., Prando C., Dalgard C.L., O'Farrelly C., Roger C., Mansouri D., van de Beek D., Vinh D.C., Hsieh E., Andreakos E., Haerynck F., Uddin F., Casari G., Novelli G., Pesole G., Meyts I., Tancevski I., Fellay J., Casanova J.L., Tur J., Kisand K., Okamoto K., Mironska K., Abel L., Renia L., Ng LFP, Shahrooei M., Soler-Palacín P., Brodin P., Pan-Hammarström Q., Halwani R., Perez de Diego R., Al-Muhsen S., Espinosa-Padilla S., Okada S., Ozcelik T., Tayoun A.A., Karamitros T., Mogensen T.H., Lau Y.L.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Publication state
Published
Issued date
15/07/2021
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.
Pubmed
Open Access
Yes
Create date
04/10/2021 10:42
Last modification date
08/10/2021 5:41
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