From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.

Arkin, L.M.; Moon, J.J.; Tran, J.M.; Asgari, S.; O'Farrelly, C.; Casanova, J.L.; Cowen, E.W.; Mays, J.W.; Singh, A.M.; Drolet, B.A.

doi:10.1016/j.jid.2021.05.024

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.

Details

Download: 34561087_BIB_867ED9E568B7.pdf (1574.78 [Ko])
State: Public
Version: Final published version
License: Not specified

Serval ID

serval:BIB_867ED9E568B7

Type

Article: article from journal or magazin.

Publication sub-type

Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.

Collection

Publications

Institution

UNIL/CHUV

Title

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.

Journal

The Journal of investigative dermatology

Author(s)

Arkin L.M., Moon J.J., Tran J.M., Asgari S., O'Farrelly C., Casanova J.L., Cowen E.W., Mays J.W., Singh A.M., Drolet B.A.

Working group(s)

COVID Human Genetic Effort

Contributor(s)

Aiuti A., Belot A., Bolze A., Bondarenko A., Sediva A., Shcherbina A., Planas A.M., Condino-Neto A., Pujol A., Drolet B.A., Catherine B., Flores C., Rodríguez-Gallego C., Prando C., Dalgard C.L., O'Farrelly C., Roger C., Mansouri D., van de Beek D., Vinh D.C., Hsieh E., Andreakos E., Haerynck F., Uddin F., Casari G., Novelli G., Pesole G., Meyts I., Tancevski I., Fellay J., Casanova J.L., Tur J., Kisand K., Okamoto K., Mironska K., Abel L., Renia L., Ng LFP, Shahrooei M., Soler-Palacín P., Brodin P., Pan-Hammarström Q., Halwani R., Perez de Diego R., Al-Muhsen S., Espinosa-Padilla S., Okada S., Ozcelik T., Tayoun A.A., Karamitros T., Mogensen T.H., Lau Y.L.

ISSN

1523-1747 (Electronic)

ISSN-L

0022-202X

Publication state

Published

Issued date

12/2021

Peer-reviewed

Oui

Volume

141

Number

Pages

2791-2796

Language

english

Notes

Publication types: Journal Article ; Review
Publication Status: ppublish

Abstract

Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.

Keywords

Animals, COVID-19/complications, COVID-19/immunology, Chilblains/complications, Chilblains/immunology, Humans, Immunity, Innate, Interferon Type I/metabolism, SARS-CoV-2/physiology

URN

urn:nbn:ch:serval-BIB_867ED9E568B73

OAI-PMH

oai:serval.unil.ch:BIB_867ED9E568B7

DOI

10.1016/j.jid.2021.05.024

Pubmed

34561087

Web of science

000722683200010

Open Access

Yes