Localized in vivo hyperpolarization transfer sequences.

Details

Serval ID
serval:BIB_84C794E9FBDF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Localized in vivo hyperpolarization transfer sequences.
Journal
Magnetic Resonance in Medicine
Author(s)
Mishkovsky M., Cheng T., Comment A., Gruetter R.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
2012
Volume
68
Number
2
Pages
349-352
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish. PDF type: Note
Abstract
In vivo localized and fully adiabatic homonuclear and heteronuclear polarization transfer experiments were designed and performed in the rat brain at 9.4 T after infusion of hyperpolarized sodium [1,2-(13)C(2)] and sodium [1-(13)C] acetate. The method presented herein leads to highly enhanced in vivo detection of short-T(1) (13)C as well as attached protons. This indirect detection scheme allows for probing additional molecular sites in hyperpolarized substrates and their metabolites and can thus lead to improved spectral resolution such as in the case of (13)C-acetate metabolism.
Keywords
Acetates/analysis, Algorithms, Animals, Brain/metabolism, Nuclear Magnetic Resonance, Biomolecular/methods, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Signal Processing, Computer-Assisted, Tissue Distribution
Pubmed
Web of science
Create date
29/04/2013 9:41
Last modification date
20/08/2019 14:44
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