The multifaceted immune regulation of bladder cancer.

Details

Serval ID
serval:BIB_84C0FB4F0070
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The multifaceted immune regulation of bladder cancer.
Journal
Nature reviews. Urology
Author(s)
Schneider A.K., Chevalier M.F., Derré L.
ISSN
1759-4820 (Electronic)
ISSN-L
1759-4812
Publication state
Published
Issued date
10/2019
Peer-reviewed
Oui
Volume
16
Number
10
Pages
613-630
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Bladder cancer is an important public health concern owing to its prevalence, high recurrence risk and treatment failures. Maintaining the equilibrium between prompt and effective immunity and an excessive and protracted immune response is critical for successful immune defence. This delicate balance is ensured by intrinsic or extrinsic immunoregulatory mechanisms. Intrinsic control of immune cell activation is mediated by stimulatory and inhibitory receptors expressed on the effector cell itself, whereas extrinsic control is mediated via other immune cells by cell-cell contact and/or secretion of inhibitory factors. Tumours can exacerbate these immunosuppressive pathways, fostering a tolerant microenvironment. These mechanisms have previously been poorly described in urothelial carcinoma, but a growing body of evidence highlights the key role of immune regulation in bladder cancer. This process includes immune checkpoints (mostly programmed cell death 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1)), as well as regulatory T cells, myeloid-derived suppressor cells, tumour-associated macrophages and type 2 innate and adaptive lymphocytes. For each component, quantitative and qualitative alterations, clinical relevance and potential targeting strategies are currently being explored. An improved understanding of immune regulation pathways in bladder cancer development, recurrence and progression will help in the design of novel diagnostic and prognostic tools as well as treatments.
Pubmed
Web of science
Create date
13/09/2019 11:12
Last modification date
17/01/2020 6:26
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