Reproducibility of retinal thickness measurements in normal eyes using optical coherence tomography.
Details
Serval ID
serval:BIB_8459
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reproducibility of retinal thickness measurements in normal eyes using optical coherence tomography.
Journal
Ophthalmic Surgery and Lasers
ISSN
1082-3069
Publication state
Published
Issued date
1998
Volume
29
Number
4
Pages
280-285
Language
english
Abstract
BACKGROUND AND OBJECTIVE: To determine the reproducibility of retinal thickness measurements in normal eyes using optical coherence tomography (OCT). PATIENTS AND METHODS: Multiple 3.20-mm vertical cross-sectional images through the center of fixation of consecutive patients with normal results on ocular examinations were obtained. Each image was divided into seven 320-micron segments. Regional retinal thicknesses for each section were measured using both the manually assisted (requiring observer localization of reflectivity peaks) and the automated modes (observer-independent measurement) of the computer software. RESULTS: Eighteen right eyes were studied. The mean coefficient of variation was less than 10% for all locations using the manually assisted method (average standard deviation less than 17 microns [range 9 to 16 microns]). The automated method was less reliable, with a coefficient of variation greater than 10% for locations within 500 microns of fixation. Automated measurements at fixation were the least reproducible because of poor internal limiting membrane reflectivity. CONCLUSION: OCT is capable of reproducible measurement of retinal thickness in normal eyes. Computer-driven, automated measurement of retinal thickness within 500 microns of fixation needs to be refined and its reproducibility reassessed in this region.
Keywords
Adult, Female, Humans, Image Processing, Computer-Assisted, Male, Observer Variation, Reference Values, Reproducibility of Results, Retina/anatomy &, histology, Tomography/methods
OAI-PMH
Pubmed
Web of science
Create date
19/11/2007 13:46
Last modification date
20/08/2019 15:44