The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland.

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Ressource 1Download: serval:BIB_84330699B06F.P001 (429.26 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_84330699B06F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland.
Journal
Journal of Infectious Diseases
Author(s)
von Wyl V., Kouyos R.D., Yerly S., Böni J., Shah C., Bürgisser P., Klimkait T., Weber R., Hirschel B., Cavassini M., Staehelin C., Battegay M., Vernazza P.L., Bernasconi E., Ledergerber B., Bonhoeffer S., Günthard H.F.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Barth J., Battegay M., Bernasconi E., Böni J., Bucher H., Bu P., Burton-Jeangros C., Calmy A., Cavassini M., Dubs R., Egger M., Elzi L., Fehr J., Fischer M., Flepp M., Francioli P., Furrer H., Fux C., Gorgievski M., Günthard H., Hasse B., Hirsch H., Hirschel B., Ho I., Kahlert C., Kaiser L., Keiser O., Kind C., Klimkait T., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., von Wyl V., Weber R., Yerly S.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
2011
Volume
204
Number
7
Pages
1095-1103
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: By analyzing human immunodeficiency virus type 1 (HIV-1) pol sequences from the Swiss HIV Cohort Study (SHCS), we explored whether the prevalence of non-B subtypes reflects domestic transmission or migration patterns.
METHODS: Swiss non-B sequences and sequences collected abroad were pooled to construct maximum likelihood trees, which were analyzed for Swiss-specific subepidemics, (subtrees including ≥80% Swiss sequences, bootstrap >70%; macroscale analysis) or evidence for domestic transmission (sequence pairs with genetic distance <1.5%, bootstrap ≥98%; microscale analysis).
RESULTS: Of 8287 SHCS participants, 1732 (21%) were infected with non-B subtypes, of which A (n = 328), C (n = 272), CRF01_AE (n = 258), and CRF02_AG (n = 285) were studied further. The macroscale analysis revealed that 21% (A), 16% (C), 24% (CRF01_AE), and 28% (CRF02_AG) belonged to Swiss-specific subepidemics. The microscale analysis identified 26 possible transmission pairs: 3 (12%) including only homosexual Swiss men of white ethnicity; 3 (12%) including homosexual white men from Switzerland and partners from foreign countries; and 10 (38%) involving heterosexual white Swiss men and females of different nationality and predominantly nonwhite ethnicity.
CONCLUSIONS: Of all non-B infections diagnosed in Switzerland, <25% could be prevented by domestic interventions. Awareness should be raised among immigrants and Swiss individuals with partners from high prevalence countries to contain the spread of non-B subtypes.
Keywords
African Continental Ancestry Group/statistics & numerical data, Asian Continental Ancestry Group/statistics & numerical data, Cluster Analysis, Emigration and Immigration, European Continental Ancestry Group/statistics & numerical data, Female, Gene Products, pol/metabolism, HIV Infections/ethnology, HIV Infections/genetics, HIV-1/genetics, HIV-1/metabolism, Heterosexuality/statistics & numerical data, Homosexuality, Male/statistics & numerical data, Humans, Likelihood Functions, Logistic Models, Male, Molecular Sequence Data, Prevalence, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
29/09/2011 9:47
Last modification date
25/09/2019 7:09
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