Focus on stereotactic radiotherapy: A new way to treat severe ventricular arrhythmias?

Details

Serval ID
serval:BIB_82755970F3AF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Focus on stereotactic radiotherapy: A new way to treat severe ventricular arrhythmias?
Journal
Archives of cardiovascular diseases
Author(s)
Sacher F., Gandjbakhch E., Maury P., Jenny C., Khalifa J., Boveda S., Defaye P., Gras D., Klug D., Laurent G., Lellouche N., Mansourati J., Marijon E., Piot O., Taieb J., Cochet H., Maingon P., Pruvot E., Fauchier L.
Working group(s)
Working Group of Cardiac Pacing, Electrophysiology of the French Society of Cardiology
ISSN
1875-2128 (Electronic)
ISSN-L
1875-2128
Publication state
Published
Issued date
02/2021
Peer-reviewed
Oui
Volume
114
Number
2
Pages
140-149
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Ventricular tachycardia has a significant recurrence rate after ablation for several reasons, including inaccessible substrate. A non-invasive technique to ablate any defined areas of myocardium involved in arrhythmogenesis would be a potentially important therapeutic improvement if shown to be safe and effective. Early feasibility studies of single-fraction stereotactic body radiotherapy have demonstrated encouraging results, but rigorous evaluation and follow-up are required. In this document, the basic concepts of stereotactic body radiotherapy are summarized, before focusing on stereotactic arrhythmia radioablation. We describe the effect of radioablation on cardiac tissue and its interaction with intracardiac devices, depending on the dose. The different clinical studies on ventricular tachycardia radioablation are analysed, with a focus on target identification, which is the key feature of this approach. Our document ends with the indications and requirements for practicing this type of procedure in 2020. Finally, because of the limited number of patients treated so far, we encourage multicentre registries with long-term follow-up.
Keywords
Action Potentials, Aged, Aged, 80 and over, Animals, Female, Heart Rate, Heart Ventricles/physiopathology, Heart Ventricles/radiation effects, Humans, Male, Middle Aged, Radiosurgery/adverse effects, Risk Factors, Tachycardia, Ventricular/diagnosis, Tachycardia, Ventricular/physiopathology, Tachycardia, Ventricular/radiotherapy, Treatment Outcome, Ablation, Catheter ablation, Radiothérapie stéréotaxique, Stereotactic body radiation therapy, Stereotactic radiotherapy, Tachycardie ventriculaire, Ventricular tachycardia
Pubmed
Web of science
Create date
08/02/2021 10:03
Last modification date
17/04/2021 6:33
Usage data