The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies.
Details
Serval ID
serval:BIB_81D29BA86AAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies.
Journal
Blood
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Publication state
Published
Issued date
28/11/2019
Peer-reviewed
Oui
Volume
134
Number
22
Pages
1941-1950
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG) exhibits modular organization related to glycan epitope structure. The current study compares the glycan-specific IgG repertoires between different PAD entities. Distinct repertoire profiles with extensive qualitative glycan-recognition defects were observed, which are characterized by the common loss of Galα and GalNAc reactivity and disease-specific recognition of microbial antigens, self-antigens, and tumor-associated carbohydrate antigens. Antibody repertoire analysis may provide a useful tool to elucidate the degree and the clinical implications of immune system failure in individual patients.
Keywords
Autoantigens/immunology, Carbohydrates/immunology, Epitopes/immunology, Female, Humans, Immunoglobulin G/immunology, Male, Primary Immunodeficiency Diseases/immunology
Pubmed
Web of science
Open Access
Yes
Create date
23/09/2019 19:15
Last modification date
03/04/2020 6:19