The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies.

Details

Serval ID
serval:BIB_81D29BA86AAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies.
Journal
Blood
Author(s)
Jandus P., Boligan K.F., Smith D.F., de Graauw E., Grimbacher B., Jandus C., Abdelhafez M.M., Despont A., Bovin N., Simon D., Rieben R., Simon H.U., Cummings R.D., von Gunten S.
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Publication state
Published
Issued date
28/11/2019
Peer-reviewed
Oui
Volume
134
Number
22
Pages
1941-1950
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG) exhibits modular organization related to glycan epitope structure. The current study compares the glycan-specific IgG repertoires between different PAD entities. Distinct repertoire profiles with extensive qualitative glycan-recognition defects were observed, which are characterized by the common loss of Galα and GalNAc reactivity and disease-specific recognition of microbial antigens, self-antigens, and tumor-associated carbohydrate antigens. Antibody repertoire analysis may provide a useful tool to elucidate the degree and the clinical implications of immune system failure in individual patients.
Keywords
Autoantigens/immunology, Carbohydrates/immunology, Epitopes/immunology, Female, Humans, Immunoglobulin G/immunology, Male, Primary Immunodeficiency Diseases/immunology
Pubmed
Web of science
Open Access
Yes
Create date
23/09/2019 18:15
Last modification date
03/04/2020 5:19
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