Circular RNA repertoires are associated with evolutionarily young transposable elements.

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Version: Author's accepted manuscript
License: CC BY-NC 4.0
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Download: Gruhl_2021_Main Suppl_R1.pdf (7967.91 [Ko])
State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_81B4CC087DBB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circular RNA repertoires are associated with evolutionarily young transposable elements.
Journal
eLife
Author(s)
Gruhl F., Janich P., Kaessmann H., Gatfield D.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
20/09/2021
Peer-reviewed
Oui
Volume
10
Pages
e67991
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Circular RNAs (circRNAs) are found across eukaryotes and can function in post-transcriptional gene regulation. Their biogenesis through a circle-forming backsplicing reaction is facilitated by reverse-complementary repetitive sequences promoting pre-mRNA folding. Orthologous genes from which circRNAs arise, overall contain more strongly conserved splice sites and exons than other genes, yet it remains unclear to what extent this conservation reflects purifying selection acting on the circRNAs themselves. Our analyses of circRNA repertoires from five species representing three mammalian lineages (marsupials, eutherians: rodents, primates) reveal that surprisingly few circRNAs arise from orthologous exonic loci across all species. Even the circRNAs from orthologous loci are associated with young, recently active and species-specific transposable elements, rather than with common, ancient transposon integration events. These observations suggest that many circRNAs emerged convergently during evolution - as a byproduct of splicing in orthologs prone to transposon insertion. Overall, our findings argue against widespread functional circRNA conservation.
Keywords
Animals, DNA Transposable Elements, Databases, Genetic, Evolution, Molecular, Gene Expression Regulation, Genetic Loci, Humans, RNA Splicing, RNA, Circular/genetics, RNA, Circular/metabolism, Species Specificity, circRNA, evolution, evolutionary biology, genetics, genomics, human, mammals, mouse, rat, rhesus macaque, splicing, transposons
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 182880
Swiss National Science Foundation / Projects / 179190
Create date
02/03/2021 9:15
Last modification date
09/11/2021 6:40
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