Actions of aldosterone on polyadenylated ribonucleic acid and Na+ transport in the toad bladder

Details

Serval ID
serval:BIB_7EBF66D8DE9C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Actions of aldosterone on polyadenylated ribonucleic acid and Na+ transport in the toad bladder
Journal
Biochemistry
Author(s)
Wilce  P. A., Rossier  B. C., Edelman  I. S.
ISSN
0006-2960
Publication state
Published
Issued date
09/1976
Peer-reviewed
Oui
Volume
15
Number
19
Pages
4279-85
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep 21
Abstract
Polyadenylated ribonucleic acid [poly(A)(+)-RNA] has been isolated from the cytoplasm of the epithelium of the urinary bladder of the toad (Bufo marinus) by oligo-(deoxythymidylate)cellulose chromatography. Aldosterone increased the incorporation of [3H]uridine, and of [3H]uridine and [3H]adenosine (given in combination) into 7S, 12S, and 18S poly(A)(+)-RNA during the first 30 min of the action of the hormone, as defined by either a pulse or pulse-chase sequence. The quantity of cytoplasmic poly(A)(+)-RNA that hybridized to [3H]poly(uridine) was also increased by aldosterone. These results are consistent with the inference of induction of messenger RNA synthesis. This effect was most marked during the first 30 min of the action of the hormone.
Keywords
Aldosterone/*pharmacology Animals Biological Transport, Active Bufo marinus Cell Nucleus/drug effects/metabolism Centrifugation, Density Gradient Cytoplasm/drug effects/metabolism Epithelium/drug effects/metabolism Female Poly A/*metabolism RNA/*metabolism Sodium/*metabolism Urinary Bladder/drug effects/*metabolism
Pubmed
Web of science
Create date
24/01/2008 13:00
Last modification date
20/08/2019 14:39
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