The benefits of integration.

Details

Ressource 1Download: BIB_7E4EEA73958C.P001.pdf (1491.78 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_7E4EEA73958C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The benefits of integration.
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Author(s)
Ciuffi A.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Publication state
Published
Issued date
04/2016
Peer-reviewed
Oui
Volume
22
Number
4
Pages
324-332
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Retroviruses, including the human immunodeficiency virus (HIV), are notorious for two essential steps of their viral replication: reverse transcription and integration. This latter property is considered to be essential for productive replication and ensures the stable long-term insertion of the viral genome sequence in the host chromatin, thereby leading to the life-long association of the virus with the infected cell. Using HIV as a prototypic example, the present review aims to provide an overview of how and where integration occurs, as well as presenting general consequences for both the virus and the infected host.

Keywords
Host-Pathogen Interactions, Humans, Retroviridae/physiology, Virus Integration
Pubmed
Open Access
Yes
Create date
10/05/2016 17:42
Last modification date
20/08/2019 14:39
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